Prodrugs and Targeted Delivery: Towards Better ADME Properties
Rautio Jarkko.
John Wiley & Sons, 2011. — (Volume 47 of Methods and Principles in Medicinal Chemistry). — 507 p. — ISBN 3527633189, 9783527633180.This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
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